药物分析中的分离技术

CHAPTER 1 INTRODUCTION TO THE PHARMACEUTIC ALANALYSIS
1．1 Nature and Tasks of Pharmaceutical Analysis
1．1．1 Pharmaceutical Analysis in the New Drug Discovery
1．1．2 Pharmaceutical Analysis to Ensure the Quality of Drug Product
1．1．3 Pharmaceutical Analysis in the Stability Studies
1．1．4 In Vivo Drug Analysis
1．2 National Standards for Supervision of Drug Quality
1．3 Significance of Separation Technology in the Pharmaceutical Analysis

CHAPTER 2 CHROMATOGRAPHIC ANALYSIS
2．1 Theoretical Principle and Parameters
2．1．1 Theoretical Principles
2．1．2 Separation Parameters
2．1．3 Theoretical Plates of a Chromatographic Column
2．2 Gas Chromatography
2．2．1 Separation Mechanism
2．2．2 GC Instrument
2．2．3 GC Columns
2．2．4 Stationary Phases in GC
2．2．5 Stationary Phases in the GSC
2．2．6 Stationary Phases in the GLC
2．2．7 Detectors in GC
2．2．8 Advantages of GC
2．2．9 Applications of GC
2．3 Introduction to Liquid Chromatography
2．3．1 Columns in HPLC
2．3．2 General Morphology of HPLC Stationary Phase Particles
2．4 Normal Phase Liquid Chromatography
2．4．1 Characteristics of Normal Phase Liquid Chromatography
2．4．2 Elution Ability of Mobile Phase
2．4．3 Applications
2．5 Reversed-phase Liquid Chromatography
2．5．1 Stationary Materials for Reversed-phase Liquid Chromatography
2．5．2 Retention Characteristic of Reversed-phase Chromatography
2．5．3 Secondary Chemical Equilibria in the Reversed-phase Chromatography
2．5．4 Applications of Reversed-phase HPLC
2．5．5 Ion-pair Reversed-phase Chromatography
2．6 Ion-exchange Chromatography
2．6．1 Separation Principle of IEC
2．6．2 Stationary Phase Materials of IEC
2．6．3 Retention of Analyses in IEC
2．6．4 Major Factors in the IEC Separation
2．6．5 Detection in IEC
2．6．6 Advantages of IEC
2．6．7 Application
2．7 Size-exclusion Chromatography
2．7．1 Separation Mechanism
2．7．2 Packing Materials for SEC
2．7．3 Applications of SEC
2．8 Affinity Chromatography
2．8．1 Nature of Affinity Interaction
2．8．2 Separation Principle of Affinity Chromatography
2．8．3 Ligand Selection
2．8．4 Selection of Supporting Materials
2．8．5 Preparation of Packing Materials for Affinity Chromatography
2．8．6 Separation by Affinity Chromatography
2．8．7 Application of Affinity Separation Technology
2．9 Thin-layer Chromatography
2．9．1 Stationary Phases Used in TLC
2．9．2 Operation in TLC
2．9．3 Performance Characteristics of TLC
2．9．4 Detection in TLC
2．9．5 Quantitative Analysis
2．9．6 Applications of TLC Analysis
2．10 Detectors in Liquid Chromatography
2．10．1 Bulk Property Detectors
2．10．2 Solute Property Detectors
References
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CHAPTER 3 HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS AND ITSAPPLICATIONIN PHARMACEUTICAL ANALYSIS
CHAPTER 4 APPLICATION OF SEPARATION TECHNOLOGYIN BIOCHEMICAL DRUG ANALYSIS AND DISEASE DIAGNOSIS
CHAPTER 5 NON-TARGETED SCREENING IN THE ANALYSIS OF COMPLEX SAMPLES WITH UNKNOWN COMPONENTS
CHAPTER 6 NEW MATERIAL DEVELOPMENT FOR PHARMACEUTICALSEPARATIONS

QUESTIONS AND PROBLEMS

INDEX