- ISBN:9787030280855
- 装帧:暂无
- 册数:暂无
- 重量:暂无
- 开本:16开
- 页数:592页
- 出版时间:2010-08-01
- 条形码:9787030280855 ; 978-7-03-028085-5
本书特色
《神经科学百科全书5:方法与技术(上导读版)》是由科学出版社出版的。
目录
节选
《神经科学百科全书5:方法与技术(上导读版)》原书篇幅巨大,为所有神经科学百科全书之首。由来自世界各地的2400多位专家撰稿人合力打造,覆盖了神经科学全部主要领域。书中每个词条在收入书中之前均经过顾问委员会的同行评议,词条中均含有词汇表、引言、参考文献和丰富的交叉参考内容。主编为著名神经科学家、美国神经科学学会前主席LarryR Squire内容平易.本科生即可读懂。深度和广度独一无二.足可满足专家学者的需要。导读版精选原书中的部分主题,按内容重新编排,更适合国内读者购买和阅读。
相关资料
Mice pose advantages over other species,such as rats,dogs,pigs,or primates,in several aspects:(1)It ISrelatively easy to house large numbers of them;(2)the mouse genome is better characterized than that of anyother mammaI except humans;(3)many geneticallyaltered transgenic knockout and knockin lines andgenetically characterized mouse strains are availablefor crossbreeding and further genetic analysis;(4)cognitive studies can be done in appropriate strains of mice,such as C5786/SJL and 129S6,making the mespecially relevant to the study of AD;and(5)studies in invertebrates,while useful,willlack some relevance in pharmacological studies and pathogenic in vestige.Tions To create transgenic mice with salient features of AD.investigators must take care in several aspects of design and development.The most important factors are the selection of the gene or gene variant to be expressed,the promoter driving transgene expression,the background strain of the mice. and the levels and distribution of transgenic protein expression achieved in the brain.The mouse lines with the most robust neuropathological phenotypes have been developed using the method of pronuclear microinjection oftransgenes into fertilized ocytes(Figure 1).B0th wildtype and variant human APP and tau genes have been used to generate mice that develop neuropathology related to AD.Transgenes containing mutations linked to aut osomaI dominant AD or FDTP generate morerobust neuropathology than transgenes encoding wild-type genes.Although mutations in presenilin一1 and presenilin.2 genes lead to early-onset ADin humans,mice expressing presenilin gene variants do not develop neuropathology per 5e.In the presence of human APP transgenes,howeve the presenilin gene variants accelerate plaque deposition in trans'genic mice.
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